Then the odds changed, Grail’s liquid biopsy test shows high sensitivity in early cancer detection, Global human microbiome market analysis & forecast, 2020—The market was valued at USD 351.81 million in 2018, Big investments for human microbiome research, Gut microbiome in type 1 diabetes: A comprehensive view, The microbiome, cancer, and cancer therapy, The battle against drugs—3D printing drugs: The latest advancements, How cellular immunotherapies are changing the outlook for cancer patients, Good food is medicine: A smart ‘farmacy’ program for diabetes patients, A randomized, placebo-controlled trial of online cognitive behavioral therapy for chronic insomnia disorder delivered via an automated media-rich web application, Effect of digital cognitive behavioral therapy for insomnia on health, psychological well-being, and sleep-related quality of life: A randomized clinical trial, Big Health wants you to cure your insomnia with its app, then delete it—and some investors hate that idea, Case study: Livongo demonstrates cost savings, Nanosponges sop up toxins and help repair tissues, A research team builds robots from living cells, Tissue-engineered human pancreatic cells successfully treat diabetic mice, Showing cybersecurity's value to health care leadership, Creating a treasure trove of data for health plans. Our interviewees suggested that other chronic diseases, such as Alzheimer’s disease, diabetes, and rheumatoid arthritis, might be treated more effectively if they are identified early. Technology embedded in a bathroom mirror might be able to distinguish a mole from melanoma. The pharmaceutical industry, once dominated by R&D-driven growth and by aggressive marketing to deliver high margins, is now under pressure and subject to considerable change. expiration,” the paper finds. The five forces, listed in order of potential disruption to the traditional scope of the biopharma industry, are: Prevention and early detection: Vaccines and improvements in wellness could help prevent disease, making treatment for some diseases no longer necessary. There must be a biological component taken into consideration in pharma advancements. It is too early to opine on the timing and impact of those activities and how the forces we describe in this paper might accelerate or change how biopharma responds to pandemics in the future. However, being at the forefront will likely require significant investments in data and analytics capabilities. Developing, marketing, and pricing these curative treatments could require the biopharma sector to adopt new capabilities. to receive more business insights, analysis, and perspectives from Deloitte Insights, Telecommunications, Media & Entertainment, Researchers develop microneedle patch for flu vaccination, A genetic test led seven women in one family to have major surgery. Giving each patient a personalized dosage, or the optimal combination of drugs, could lead to better outcomes. More sophisticated medical technology might enable earlier interventions and more effective procedures that reduce or even eliminate the need for pharmaceutical management. How will each of these five forces disrupt our current business model? Early detection: Emerging technologies could dramatically improve our ability to detect disease in its earliest stages. They include prevention and early detection, custom treatments and personalized medicine, curative therapies, digital therapeutics, and precision intervention. He has worked extensively with clients to develop and commercialize breakthrough products in oncology, immunology, and liver disease. Indian companies such as Ranbaxy, Sun Pharma, and Dr. Reddy's are increasingly focusing on tapping the U.S. generic market. Advances in early detection will likely enable interventions that halt diseases in the earliest stages—before they progress to more serious conditions. The future of health that we envision in 2040 will be a world apart from what we have now. This had had a more mixed result. View in article, Neil Lesser and Bushra Naaz, Master protocols: Shifting the drug development paradigm, Deloitte Insights, September 17, 2018. How can we continue to monitor the landscape for future disruption. Using cognitive and behavioral therapy techniques to address sleep disorders, the app strives to be entertaining as well as tailored to each user. The changes that we see on the horizon will likely require biopharma companies to consider new types of markets, alternative business models, or a complete change in how they define what work they do. Our people know how to anticipate, collaborate, innovate, and create opportunity from even the unforeseen obstacle. In response, they were able to change their diets and lifestyle habits to avoid those triggers. In some applications, 3D printing offers solutions where none existed. One interviewee said he expects to “see cures for diseases that are well-defined by genetic mutations based on better gene therapy.” Such diseases could include cystic fibrosis, sickle cell disease, fragile X syndrome, muscular dystrophy, and Huntington’s disease. The pharmaceutical industry has a number of unusual characteristics, both in its structure and in the nature of its business operations, which are little known outside the industry but which materially affect the process of bringing new pharmaceuticals to the patient. Unlike today, we believe care will be organized around the consumer, rather than around the institutions that drive our existing health care system. Over the next 20 years, more vaccines could be developed that prevent more types of cancer. Modern medicine is nothing short of miraculous, especially compared with the medicine of even a decade or two ago. See something interesting? One important consequence is the demise of the strategy that required production to be carried out locally to its market. Some of our interviewees noted that the ability to use genetic information to identify patients at risk for developing disease could create an opportunity for biopharma companies. We can already see these trends taking shape as the pharma industry is expected to see annual compound growth of over 6% and reach $1.2 trillion in 2024, with R&D spending at 16.9% ofprescription sales in 2024.”, “Pharma will become increasingly reliant on digital tools and data-driven strategies from drug development through commercialization. Genetic testing: Whole-genome sequencing is a powerful and revolutionary tool. View in article, The Editorial Board, “Good food is medicine: A smart ‘farmacy’ program for diabetes patients,” Pittsburgh Post-Gazette, April 23, 2018. During the next 20 years, biopharma companies might get close to the process of sourcing these raw materials and could consider using them to treat disease. Drug therapy might still be required to manage other variables that drive disease expression. View in article, Alliance for Regenerative Medicine, “Clinical trials: Q3 2019,” accessed February 25, 2020. View in article, Sriram Renganathan, “The battle against drugs—3D printing drugs: The latest advancements,” All3DP, February 23, 2019. If the future of health emerges in the way we expect it will, we could see some consolidation among generic-drug manufacturers. Some of these digital interventions have been FDA-approved and health plans and pharmacy benefit managers (PBMs) are paying for them. ABOUT AUTHOR: Shrikant Ojha Department of Quality Assurance Techniques, Sinhgad College of Pharmacy, Vadgaon (Bk. In fact, the genetic testing market is expected to reach US$17.6 million by 2025 with a CAGR of 11.3 percent.4 Early detection of a disease, or the ability to determine who might be genetically predisposed to a disease, could make it possible to cure an illness in the early stages or prevent it altogether. COPYRIGHT © 2018 DISRUPTORDAILY.COM. Case in point: In December 2019, the Wall Street Journal reported that seven women from the same family underwent major surgeries after a genetic test determined they all had an elevated risk of developing breast cancer.5 Since then, we’ve learned the increased risk associated with this particular gene is not quite as high as previously thought. I predict that the pharma company of the future will not be a single company but rather a decentralized family of companies akin to Alphabet or Tencent, building innovative biotech companies from scratch while making long-term investments in a shared technology platform—harvesting economies of scale where appropriate, but also maintaining entrepreneurial focus at individual companies.”, “The future I see with the pharmaceutical industry is individualizing care. Curative therapies—time-limited treatments that remove symptoms of a disease through the permanent (or semipermanent) correction of the underlying condition—have the potential to reduce the incidence and prevalence of many diseases. Shifts in how diseases are identified, prevented, treated, or cured may lead to fundamentally different business models for traditional biopharma companies and new entrants. ), Pune -411041, Maharashtra, India. Microbes found in the guts of children, for example, could be related to childhood diseases, such as Type 1 diabetes.9 Recent research also suggests that the microbiome could influence how susceptible a patient might be to certain types of cancer, or how a patient is likely to respond to immunotherapy.10. Explore what the future of the pharmaceutical industry holds and how health interventions may impact business models in life sciences. View in article, Esther Landhuis, “Nanosponges sop up toxins and help repair tissues,” Science News, March 7, 2019. Global Regulatory Affairs, Allergan, Irvine, CA, USA . View in article, Amy Dockser Marcus, “A genetic test led seven women in one family to have major surgery. Some interviewees were skeptical of the long-term adoption, or stickiness, of digital therapeutics. They suggest that bots derived in a similar manner, using the person’s own cells, could be injected into the bloodstream to remove plaque from artery walls.25, 3D printing and tissue engineering: Manufacturers and clinicians could use 3D printing to create highly customized, low-cost medical technology products that are tailored to each patient’s unique physiology. The current model of selling therapies that treat symptoms or mitigate the progression of chronic diseases is no longer viable. Non-negotiable, however, is that these technologies need to demonstrate results. We define a customized treatment as a single therapy, or mix of therapies, that is selected, tailored, or developed to treat an individual. As researchers reduce the cost of making and delivering these therapies, and reduce or better manage toxicities, they could move upstream in treatment plans to become the standard of care. Not unexpectedly, the pharmaceutical industry has aggressively partnered with biotechnology companies to fill their pipeline gaps. We strongly believe that only digital health can bring healthcare into the 21st century and make patients the point-of-care. Meanwhile, the amount of seniors (65+ years old) in the U.S. will double to 100 million by 2060. In terms of the global market, India currently holds a modest 1-2% share, … In this future of health, the era of blockbuster drugs that treat large populations will likely wane. For example, the home bathroom of the future might include a smart toilet that uses always-on sensors to test nitrites, glucose, protein, and pH for possible infections or disease. As Cell and Gene Therapy manufacturing differs considerably from chemical drug production, pharma companies will have to develop new processes to address the challenges along key phases of the product life cycle.”, Have expert insights to add to this article? 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Digital therapeutics deliver evidence-based interventions to patients through software programs that help prevent, manage, or treat a medical disorder or disease. Discover Deloitte and learn more about our people and culture. Sales volumes for drugs across disease areas are likely to decline due to more effective prevention, greater stratification of disease, better tailoring of drug regimens for patients, an increase in curative therapies, behavioral intervention, and advanced medical procedures. Future Prospects. We observe a global trend towards combining pharmaceuticals with … Real-time tracking of drug therapy and symptoms allow doctors and coaches to intervene and modify therapy before symptoms escalate. Vaccines and other early interventions could prevent a greater number of diseases from developing in the first place. The pharmaceutical contract packaging market is driven by rising R&D spending in the pharmaceutical industry. Gene Therapy is the introduction, removal, or change in the structure of a patient’s genetic code to treat or cure a disease. Lastly, companies might need to explore novel financing mechanisms to enable both access and affordability given that the short-duration treatment has the potential for a life time of benefit. 377–88. For example, airway splints for babies with tracheobronchomalacia (a rare condition where the tracheal or windpipe cartilage is soft) can be created by a 3D printer.26, Tissue engineering—in combination with additive manufacturing—could be used to restore damaged tissues. This could be similar to how doctors are now able to sequence tumors, identify mutations, and match the appropriate therapy in cancer patients. The credit crunch has increased cost pressures on the pharmaceutical industry, Capgemini suggests that part of its response could be to open up a dialogue about the wider healthcare agenda. Research methods are evolving and we have many promising prospects on the horizon – from the possibilities offered by personalised medicines, to the potential offered by harnessing the power of big data. Emphasis on strategically working with regulators to reduce or at least stabilize prices for vulnerable populations continue to occupy regulators in the U.S. and worldwide.”, “A major focus of Pharma going forward will be a move toward instituting new manufacturing technologies to produce biologic drugs and vaccines. Questions about how the cost and benefits for a one-time curative treatment should be allocated need to be addressed. Increased focus on nutrition, for example, could mean fewer people have high cholesterol, which would translate to a smaller market for generic statins. ALL RIGHTS RESERVED. Most of these therapies target diseases driven by a single or a few genetic mutations. “We’ll be able to fix it, regenerate tissue, or grow replacements, perhaps through xenotransplantation,” he predicted. The Pharma industry as a whole is moving toward consolidation with more and more manufacturers, PBMs, pharmacies merging with one another to achieve control over data and market share. As one interviewee pointed out, “There is no way to determine why some people develop rheumatoid arthritis and some people don’t.” But the groundwork is already being laid for a world with a greater ability to detect and prevent disease. Express Scripts, for example, has established a digital formulary that evaluates digital interventions based on clinical research, usability, and financial value.16 Livongo’s digital therapeutics for diabetes, prediabetes, and hypertension have received preferred formulary status (see the sidebar, “New digital therapeutics help patients manage their chronic diseases”). Nanotechnology: Microscopic nanotechnology particles have the potential to enter diseased tissues and deliver more targeted and precise medical interventions. Biopharma companies might be able to develop or target therapies to the unique characteristics of each subpopulation. The goal of harnessing these technologies will be to avoid the relatively high production cost and low efficiency inherent in conventional methods of drug production. Forces disrupt our current business each of its member firms are legally separate and entities! 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